The NAD+-mediated self-inhibition mechanism of pro-neurodegenerative SARM1

Neurotoxins subvert the allosteric activation mechanism of SARM1 to induce neuronal loss

Structural basis for SARM1 inhibition and activation under energetic stress

SARM1 is a metabolic sensor activated by an increased NMN/NAD+ ratio to trigger axon degeneration - ScienceDirect

SARM1, an Enzyme Involved in Axon Degeneration, Catalyzes Multiple Activities through a Ternary Complex Mechanism

SARM1 is a metabolic sensor activated by an increased NMN/NAD+ ratio to trigger axon degeneration - ScienceDirect

Uncompetitive, adduct-forming SARM1 inhibitors are neuroprotective in preclinical models of nerve injury and disease - ScienceDirect

The curious case of SARM1: Dr. Jekyll and Mr. Hyde in cell death and immunity? - Sarkar - 2023 - The FEBS Journal - Wiley Online Library

SARM1 is a metabolic sensor activated by an increased NMN/NAD+ ratio to trigger axon degeneration - ScienceDirect

Acidic pH irreversibly activates the signaling enzyme SARM1 - Zhao - 2021 - The FEBS Journal - Wiley Online Library

SARM1 activation and its downstream pathways are distinct in neuronal compartments